Equilibrium and kinetic studies on ligand substitution reactions of chloromethyl(aquo)cobaloxime with aromatic and aliphatic N-donor ligands

Journal of Chemical Sciences

D Sudarshan Reddy¹  S Satyanarayana1¹ 

[1] Department of Chemistry, Osmania University, Hyderabad 500 007, India$$

关键词: Alkylcobaloximes;    ligand substitution reactions;    hard and soft ligands.;   

DOI  :  

来源: Indian Academy of Sciences

【 摘 要 】

Equilibria and kinetics of the reactions of chloromethyl(aquo)cobaloxime with histamine, histidine, glycine and ethyl glycine ester were studied as a function of pH at 25°C, 1.0 M ionic strength (KCl) by spectrophotometric techniques. Comparison of equilibrium constants and rate constants tells that the order is 𝐾Hisdn > 𝐾Hiamn > 𝐾Gly > 𝐾EtGlyest. The rate of substitution of H2O varies with the p𝐾𝑎 of the incoming ligand and nucleophilic participation of the ligand in the transition state. The rate constants and equilibrium constants are correlated to the hardness and softness of the ligands and the Co(III) of cobaloxime.

【 授权许可】

Unknown