期刊论文详细信息
Cardiorenal Medicine
Fibroblast Growth Factor 23 and Hypophosphatemia: A Case of Hypophosphatemia along the Rickets-Osteomalacia Spectrum
O. Nájera1  George T. Georges1  James R. Sowers1  Kurt Sowers1 
[1] $$
关键词: Osteomalacia;    Fibroblast growth factor 23;    Phosphorus;   
DOI  :  10.1159/000449476
学科分类:心脏病和心血管学
来源: S Karger AG
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【 摘 要 】

Phosphorus is a key component of bone, and a deficiency results in poor mineralization along with other systemic symptoms of hypophosphatemia. Various causes of hypophosphatemia with renal wasting of phosphorus have been identified. These include the Fanconi syndrome, various genetic mutations of fibroblast growth factor 23 (FGF23) handling and the sodium/phosphate cotransporter, and those due to FGF23 secretion by mesenchymal tumors. Depending on the cause, vitamin D metabolism may also be impaired, which may amplify the deficiency in phosphorus and render treatment more challenging. Here, we report a case of hypophosphatemia and multiple stress fractures in a 20-year-old male college student living with chronic bone pain and anxiety about suffering further fractures. We further review the literature regarding this spectrum.

【 授权许可】

Unknown   

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