Effects of Acanthopanax divaricatus var. albeofructus in mice submitted to protein restriction

Oriental Pharmacy and Experimental Medicine

Chan-Won Park²  Hyun-Ja Jeong²  Hyung-Min Kim¹  Kyu-Yeob Kim¹  In-Cheol Kang² 

[1] Kyung Hee University$$;Hoseo University$$

关键词: Immune-regulation effect;   

DOI  :  10.1007/s13596-011-0005-7

学科分类：药学

来源: Springer

【 摘 要 】

The present study was to investigate the effects of water extracts of Acanthopanax divaricatus var. albeofructus stem extract (ADE) on an exacerbated immune function through utilization of a protein-energy malnutrition (PEM) diet. ADE has been used in Korea as a tonic and sedative agents as well as a drug with ginseng like activities. However, there is no pronouncing about the immune system on the PEM feeding mice. The immobility time were significantly decreased in the ADE-administrated group as compared to the control group on the forced swimming test (P < 0.05). The level of aspartate aminotransferase and lactate dehydrogenase in blood was significantly reduced in the ADE-administrated group (P < 0.05). ADE also significantly decreased production of interferon-γ and interleukin (IL)-4 but not IL-2 in splenocytes (P < 0.05). We used a manually antibody microarray to carry out the signaling protein microarray analysis. Unfortunately, we did not find change of protein expression. These results suggest that ADE have the anti-fatigue effect and the immune regulation effect.

【 授权许可】

Unknown