Effects of TiO2 nanoparticles and nanotubes on zebrafish caudal fin regeneration

Molecular & Cellular Toxicology

Hyung-Geun Park¹  Min-Kyeong Yeo¹ 

[1]Kyung Hee University$$

关键词: Zebrafish caudal fin;   

DOI  :  10.1007/s13273-013-0046-8

学科分类：分子生物学，细胞生物学和基因

来源: Korean Society of Toxicogenomics and Toxicoproteomics

【 摘 要 】

Nanophase ceramic titanium dioxide (TiO₂) is a potential scaffold material for tissue engineering. When scaffolds are used to regenerate injured tissues or organs, potential adverse effects associated with the scaffolding material should be investigated. This study focused on the influx and accumulation of TiO₂ nanoparticles (NPs)- and TiO₂ nanotubes (NTs)- and the resulting damage to zebrafish caudal fin regeneration. The effects of these nanomaterials on apoptosis or necrosis during embryogenesis were also investigated. NPs and NTs induced asymmetric regeneration of fins at 1 mg/L, and apoptosis was observed in zebrafish embryos exposed to NPs and NTs at 20 ng/L. Significantly more TiO₂-NPs and TiO₂-NTs accumulated in reproductive organs and intestines of fish with amputated fins, suggesting that TiO₂-NPs and TiO₂-NTs cause undesired tissue accumulation and toxicity. Thus, bioaccumulation of TiO₂ nanomaterials in intestine and reproductive organs via injured tissue could be a potential developmental risk.

【 授权许可】

Unknown