Subchronic oral toxicity of herbal formula PM012 in Beagle dogs

Molecular & Cellular Toxicology

Dong Wook Kim¹  Hyunsu Bae¹  Insop Shim¹  Hwan-Suck Chung¹  Sun Kwang Kim¹  Han Kyum Kim¹ 

[1] Kyung Hee University$$

关键词: Oriental medicinal prescription;   

DOI  :  10.1007/s13273-014-0037-4

学科分类：分子生物学，细胞生物学和基因

来源: Korean Society of Toxicogenomics and Toxicoproteomics

【 摘 要 】

PM012 is a modified oriental medicinal prescription based on Yukmijihwang-tang.We previously reported that PM012 has a neuro-protective effect and has no toxicity with chronic administration in rats. As a process of the development of herbal new drug, we assessed the oral toxicity of PM012 in Beagle dogs. PM012 was administered orally for 28 days at doses of 0, 250, 500, 1000 and 1500 mg/kg/day. When we analyzed the body weight gain, food consumption, clinical observations, blood biochemical, hematology, organ weight ratios and histopathological findings, there were no significant differences between the control and treated groups. It was concluded that orally administered PM012 was safe in dogs, and no treatment-related toxicity was detected, even at the highest doses investigated in repeated dose oral toxicity studies.

【 授权许可】

Unknown