Evaluation of comparative cytotoxicity of spray-type chemicals used in household products

Molecular & Cellular Toxicology

Ilseob Shim²  Pilje Kim²  Gyun-Baek Seo³  Kyunghee Choi²  Ji-Youn Jung¹  Jung-Taek Kwon²  Hyun-Mi Kim²  Byoungcheun Lee² 

[1] Kongju National University$$;National Institute of Environmental Research$$;National Institute of Environmental Research$$Kongju National University$$

关键词: Citral;   

DOI  :  10.1007/s13273-013-0008-1

学科分类：分子生物学，细胞生物学和基因

来源: Korean Society of Toxicogenomics and Toxicoproteomics

【 摘 要 】

Chemicals are widely used in our daily lives for various purposes such as disinfectant, air fresher, paints and hair spray. However, their pulmonary toxicity has less studied compared with oral and dermal toxicity. Therefore, the purpose of this study was to examine comparative cytotoxicity of triclosan (TCS), benzisothiazolinone (BIT), dichlorophene (DCP) and citral (CTR) major using spray-type chemicals used in household products (CHPs) in Korea. TCS, DCP and BIT induced more severe mitochondria injury and cell membrane damage than CTR in lung epithelial cell during 24 hrs exposure. Furthermore, the result of clonogenic assay revealed that exposure of CHPs significantly decreased colony size and that BIT reduced cell growth at most compared with TCS, DCP and CTR. In summary, results of comparative cytotoxicity demonstrated that inhalation of TCS, DCP and BIT may cause pulmonary toxicity. Therefore, our results suggest that TCS, BIT and DCP are requiring inhalation toxicity assessment for maintaining a high quality of life.

【 授权许可】

Unknown