Genomic comparison of insecticides and herbicide in human hepatoma (HepG2) cell line

Molecular & Cellular Toxicology

Youn-Jung Kim³  Yu Ri An²  Hey-Won Park⁴  Seung-Jun Kim⁵  Jae-Chun Ryu³  Moon-Ju Oh¹  Seung Yong Hwang⁵ 

[1]GenoCheck Co. Ltd.$$

[2]Hanyang University$$

[3]Korea Institute of Science & Technology$$

[4]GenoCheck Co. Ltd.$$Hanyang University$$

[5]Hanyang University$$GenoCheck Co. Ltd.$$

关键词: Functional analysis;   

DOI  :  10.1007/s13273-010-0050-1

学科分类：分子生物学，细胞生物学和基因

来源: Korean Society of Toxicogenomics and Toxicoproteomics

【 摘 要 】

Pesticide is a chemical substance, biological agent, antimicrobial, disinfectant or device used against any pest, and it can be grouped in several different ways. Atrazine is one of the most commonly used herbicides found in the rural environments, permethrin and prallethrin are pyrethroid insecticides. In this study, we compared the characters of herbicide and insecticide by cytotoxicity and microarray experiments. In the cytotoxicity tests, we couldn’t find specific chemical features. However, in the gene expression analysis, we found that insecticides affects to RNA processing and RNA metabolism, and especially, in the energy metabolism, such as generation of precursor metabolites and energy, and energy derivation by oxidation of organic compounds, herbicides and insecticides are differently working. This study provides characteristics of two pesticides by checking the transcriptional change.

【 授权许可】

Unknown