Overexpression of Autophagy-Related 16-Like 1 in Patients with Oral Squamous Cell Carcinoma

Pathology & Oncology Research

Jen-Yang Tang³  Edward Hsi⁴  Hsueh-Wei Chang⁴  Pei-Yi Chu²  Ya-Chun Huang⁵  Nicholas Chung-Heng Hsu⁴  Chee-Yin Chai¹  Wen-Chi Yang⁵ 

[1] Kaohsiung Medical University Hospital$$National Sun Yat-Sen University$$;St. Martin De Porres Hospital$$Fu-Jen Catholic University$$;Kaohsiung Medical University$$Kaohsiung Medical University Hospital$$;Kaohsiung Medical University$$;Kaohsiung Medical University Hospital$$

关键词: Autophagy-related 16-like 1;   

DOI  :  10.1007/s12253-014-9821-7

学科分类：生理学与病理学

来源: Springer

【 摘 要 】

Dyregulation of autophagy has been reported in various human cancers including oral squamous cell carcinoma (OSCC). The objective of this study was to link expression of autophagy-related 16-like 1 (ATG16L1), a protein essential for autophagosome formation, to clinical outcome in a cohort of 90 OSCC patients. Expression level of ATG16L1 was assessed by immunohistochemistry and an immunoreactivity score (IRS), ranging from 0 to 9, was assigned to each case. The results were correlated with clinicopathological parameters and outcome of patients. Twenty-seven patients (30 %) exhibited ATG16L1 overexpression as indicated by an IRS of 9. Overexpression of ATG16L1 was significantly associated with disease stage (p�?=�?0.001), size (p�?=�?0.031) of the tumor, lymph node metastasis (p�?=�?0.004), and histological grade (p�?=�?0.038). ATG16L1 overexpression significantly affected the overall survival (p�?=�?0.020) and time to recurrence (p�?=�?0.031) of OSCC patients in Kaplan-Meier analysis. The present study suggested that ATG16L1 may be used as a biomarker for selecting OSCC patients with a more aggressive phenotype.

【 授权许可】

Unknown