Polymorphisms in the MUC16 Gene: Potential Implication in Epithelial Ovarian Cancer

Pathology & Oncology Research

Abdelhédi Miled¹  Hassen Hadj Kacem³  Houda Bouanene¹  Halima Ben Limem¹  Leila Ben Fatma²  Salwa Yakoub⁴  Slim Ben Ahmed² 

[1] Laboratory of Biochemistry—CHU Farhat Hached$$;Service of Oncology—CHU Farhat Hached$$;Center of Biotechnology$$;Center of Blood Transfusion$$

关键词: Epithelial ovarian cancer;   

DOI  :  10.1007/s12253-010-9314-2

学科分类：生理学与病理学

来源: Springer

【 摘 要 】

MUC16 plays an important role in epithelial ovarian cancer. In this paper, we studied the association between two tags SNPs of MUC16 and the risk of epithelial ovarian cancer. We aimed also to test the association between these tags SNPs and elevated level of the protein CA125. We analyzed a collection of 117 cases. Forty-one samples of patients with epithelial ovarian cancer and 76 samples from Tunisian volunteers were genotyped for two synonymous coding tags SNPs of the MUC16 gene (rs1596797, A/C and rs2547065, C/G) using polymerase chain reaction and sequencing. For the rs1596797 SNP, there was no significant difference in genotype distribution, a rare variation observed in only one patient. For the polymorphism rs2547065, mean CA125 levels were 24 and 78 UI/ml in patients with GG and GC genotypes versus 230 UI/ml in patients with CC genotype (P�?=�?0.36). Compared to the C/C genotype, the ‘G�? allele (C/G+G/G genotypes) did not significantly modified the risk of developping epithelial ovarian cancer (OR�?=�?0.43; 95% CI). As for the polymorphism rs1596797, compared to the C/C genotype, the ‘A�? allele (C/A+A/A genotypes) did not significantly modified the risk of developping epithelial ovarian cancer (OR�?=�?881.7; 95% CI). MUC16 gene polymorphisms selected in this study are neither involved in genetic predisposition to epithelial ovarian cancer nor associated with CA125 level.

【 授权许可】

Unknown