Effects of the Inhibition of Cyclooxygenase-2 on Human Esophageal Cancer Cells: Inhibition of Cell Proliferation and Induction of Apoptosis

Pathology & Oncology Research

Yong-dong Wu¹  Shu-tian Zhang¹  Jun Tu⁴  Cai-min Xu²  Zhong-lin Yu¹  Li Zhang³ 

[1] Capital University of Medical Sciences$$;Chinese Academy of Medical Sciences$$;Capital University of Medical Sciences$$University of Nebraska Medical Center$$;University of Texas at San Antonio$$

关键词: Synergistic effect;   

DOI  :  10.1007/s12253-009-9185-6

学科分类：生理学与病理学

来源: Springer

【 摘 要 】

Cyclooxygenase-2 (COX-2) has been shown to be upregulated in a variety of tumors so that COX-2 may be a potential target in the treatment of cancer. In order to further explore the mechanism, we used RNA interference to study effects of the inhibition of COX-2 on esophageal squamous cell carcinoma (ESCC) lines. Western blot analysis demonstrated that COX-2 expression was significantly reduced in ESCC cells treated with the COX-2-specific siRNA. Furthermore, the COX-2 siRNA treatment inhibited cell proliferation and induced apoptosis in ESCC cells. In addition, the combination treatment of COX-2 siRNA and acidum acetil salicylicum (aspirin) has a synergistic effect. Therefore, this combination has potential as an anticancer therapy for the treatment of ESCC.

【 授权许可】

Unknown