Zonula Occludens-1, Occludin, and E-cadherin Protein Expression in Biliary Tract Cancers

Pathology & Oncology Research

Hajnalka Győrffy¹  Júlia Németh¹  Péter Kupcsulik¹  Attila Szíjártó¹  Péter Tátrai¹  Áron Somorácz¹  Attila Marcell Szász¹  Zsuzsa Schaff¹  András Kiss¹  Zsuzsanna Németh¹ 

[1] Semmelweis University$$

关键词: Tight junction;   

DOI  :  10.1007/s12253-009-9150-4

学科分类：生理学与病理学

来源: Springer

【 摘 要 】

The incidence of cholangiocarcinomas originating from intrahepatic and extrahepatic bile ducts, as well as of gallbladder carcinoma is increasing worldwide. The malignant transformation of biliary epithelia involves profound alterations of proteins in the intercellular junctions, among others zonula occludens-1 (ZO-1), occludin, and E-cadherin. Each plays important role in the maintenance of epithelial cell polarity and regulation of cell growth and differentiation. Our aim was to investigate ZO-1, occludin, and E-cadherin immunohistochemical reactions in tissue microarray blocks containing 57 normal and 62 neoplastic biliary tract samples. We demonstrated that the tight junction components ZO-1, occludin, and E-cadherin are downregulated in carcinomas arising from various compartments of the biliary tract (normal intrahepatic and extrahepatic bile ducts, gallbladder) as compared with their normal sites of origin. These results were confirmed by discriminant analysis yielding clear separation of the three normal sample groups from carcinomas in the corresponding locations.

【 授权许可】

Unknown