Delayed Hematological Recovery Following Autologous Transplantation Utilizing Peripheral Blood Stem Cells Harvested After Treatment with Arsenic Trioxide

Pathology & Oncology Research

Minako Jinta¹  Toshimitsu Ueki¹  Kiyoshi Hiruma¹  Hideki Akiyama¹  Kazuteru Ohashi¹  Hisashi Sakamaki¹  Yoshiki Okuyama¹ 

[1] Komagome Hospital$$

关键词: Autologous PBSCT;   

DOI  :  10.1007/s12253-008-9049-5

学科分类：生理学与病理学

来源: Springer

【 摘 要 】

We describe herein two cases of delayed hematological recovery (DHR) following autologous peripheral blood stem cell transplantation (auto-PBSCT) using cells harvested during second molecular remission after treatment with arsenic trioxide (As₂O₃). Current therapeutic strategies with As₂O₃ plus auto-PBSCT might be hampered by potential mechanisms of DHR. Our observations highlight the need for study of the real effects of As₂O₃ on the kinetics of normal hematopoietic engraftment following auto-PBSCT.

【 授权许可】

Unknown