Primary bone marrow T-cell anaplastic large cell lymphoma with triple m gradient

Pathology & Oncology Research

Árpád Szomor²  Georges Delsol¹  Zsuzsanna Szijártó²  Hajna Losonczy²  László Kereskai²  Talal Al Saati¹ 

[1] Central Hospital University Purpan$$;University of Pécs$$

关键词: bone marrow;   

DOI  :  10.1007/BF02893508

学科分类：生理学与病理学

来源: Springer

【 摘 要 】

We present a case of a 60-year-old male patient with primary bone marrow anaplastic large cell lymphoma. He was admitted to the hospital with the symptoms of anemia and fever. There was no evidence of lymphadenopathy or splenomegaly. Immunoelectrophoresis showed the presence of a triple M gradient (double IgM and an IgG), with the IgG and one of the IgM paraproteins functioning as a cryoglobulin. The patient had no hepatitis C virus infection. Bone marrow biopsy showed massive CD30-positive, ALK-negative large lymphoid cell infiltration of T-cell origin with anaplastic morphology. PCR analysis of lymphoid cells separated from the bone marrow demonstrated the presence of a B/T hybrid genotype disorder with no evidence of the t(2;5), nor t(1;2) translocations. The patient entered a period of remission following CHOP chemotherapy. The patient subsequently died of sepsis as a consequence of serious humoral immunodeficiency.

【 授权许可】

Unknown