Salvage chemotherapy with donor lymphocyte infusion and STI 571 in a patient relapsing with B-lymphoblastic phase chronic myeloid leukemia after allogeneic bone marrow transplantation

Pathology & Oncology Research

Anikó Barta²  János Dolgos²  Gabriella Halm²  Katalin Pálóczi¹  László Gopcsa²  Anikó Bányai² 

[1] National Medical Center$$Semmelweis University$$;National Medical Center$$

关键词: STI 571;   

DOI  :  10.1007/BF03033758

学科分类：生理学与病理学

来源: Springer

【 摘 要 】

Relapse is the main cause of treatment failure following hematopoietic stem cell transplantation for blastic phase chronic myeloid leukemia. Treatment options including donor lymphocyte infusion, second transplantation, interferon- and re-induction chemotherapy are often unsuccessful. We report a patient with blastic phase chronic myeloid leukemia relapsing after allogeneic stem cell transplantation. The post-transplant leukemia was characterized with B-lymphoid markers and multiple genetic abnormalities including double Ph-chromosomes. The disease was treated with three courses of salvage chemotherapy combined with donor lymphocyte infusion and bcrabl tyrosine kinase inhibitor. The leukemia proved to be non-responsive both to immune therapy and STI 571. The presented case demonstrates the need for combination approaches in post-transplant relapsed leukemia and discusses the possible contributing mechanisms of STI-571 resistance.

【 授权许可】

Unknown