Molecular pathology of tumor metastasis

Pathology & Oncology Research

Orsolya Csuka¹  László Kopper²  Zsolt Orosz¹  András Jeney²  József Tímár³ 

[1] National Institute of Oncology$$;Semmelweis University$$;National Institute of Oncology$$Semmelweis University$$

关键词: malignant melanoma;   

DOI  :  10.1007/BF03032353

学科分类：生理学与病理学

来源: Springer

【 摘 要 】

Millenium reviews of oncology agreed that the last century produced major developments mainly in the management of the primary tumor, but despite all of these results, cancer still remains among the leading causes of death due to the failure of clinical management of disseminated disease. This failure is primarily due to the lack of detailed information on the molecular mechanisms of tumor metastasis. Therefore, one of the hottest fields in experimental oncology is metastasis research, which provides more and more information about the molecular mechanisms. However, this information is fragmented and is not yet exploited in clinical practice. A new field of diagnostic pathology recently emerged, which translates basic research data to diagnostic practice to provide clinically relevant information on the biological potential (in this case metastatic potential) of the malignant tumors. Since tumor cell-extracellular matrix interactions are key features of tumor dissemination, expression of genes responsible for them can define the metastatic potential of malignant tumors. This review summarizes our recent knowledge on the metastatic geno-and phenotype of major human solid tumors: lung, colon, breast, prostate cancers and malignant melanoma.

【 授权许可】

Unknown