Immunohistochemical expression of N-ras oncogene is a late event in head and neck carcinomas

Pathology & Oncology Research

Julie Neanen²  Eric Okum²  Keith M. Wilson¹  Ljiljana Pavelic¹  Robert L. Sonkk¹  John S. McDonald¹  Peter Gartside¹  Zlatko P. Pavelic¹  Jack L. Gluckman¹ 

[1] University of Cincinnati College of Medicine$$;Ohio State University$$

关键词: N-ras;   

DOI  :  10.1007/BF02893944

学科分类：生理学与病理学

来源: Springer

【 摘 要 】

This study investigated the expression of the N-ras oncogene in routinely processed tissue sections from 133 patients with squamous cell carcinoma of the head and neck (SCCHN) by immunohistochemistryusing anti-N-ras monoclonal antibody. N-ras expression was present in 67 of 133 (49.67%) cases. There was a highly significant correlation between N-ras expression and clinical stage of disease (P=0.003). This study confirmed that overexpression of the N-ras oncogene is common in SCCHN and that it may be an important event in the late stage of disease.

【 授权许可】

Unknown