Natural antisense RNAs as mRNA regulatory elements in bacteria: a review on function and applications

Cellular & Molecular Biology Letters

Mehdi Kamali³  Mehrdad Moosazadeh Moghaddam²  Fatemeh Saberi¹  Ali Najafi¹  Alavieh Yazdanparast² 

[1] Molecular Biology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran$$;Applied Biotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran$$;Nanobiotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran$$

关键词: Bacteria;    Natural antisense;    Regulation;    Riboswitch;    Hfq protein;    RNA engineering;    RNA silencing;    RNA thermosensors;   

DOI  :  10.1186/s11658-016-0007-z

学科分类：分子生物学，细胞生物学和基因

来源: Uniwersytet Wroclawski * Wydzial Biotechnologii / University of Wroclaw, Faculty of Biotechnology

【 摘 要 】

Naturally occurring antisense RNAs are small, diffusible, untranslated transcripts that pair to target RNAs at specific regions of complementarity to control their biological function by regulating gene expression at the post-transcriptional level. This review focuses on known cases of antisense RNA control in prokaryotes and provides an overview of some natural RNA-based mechanisms that bacteria use to modulate gene expression, such as mRNA sensors, riboswitches and antisense RNAs. We also highlight recent advances in RNA-based technology. The review shows that studies on both natural and synthetic systems are reciprocally beneficial.

【 授权许可】

Unknown