Regulation of lncRNA expression

Cellular & Molecular Biology Letters

Aimin Ji¹  Bohong Cen¹  Houliang Deng¹  Li Liu¹  Zhuomin Wu¹  Xiaoxia Liu¹  Qian Xu¹  Jingjing Zhang¹ 

[1] Center for Drug Research and Development, Zhujiang Hospital, Southern Medical University, Zhujiang, China$$

关键词: lncRNAs;    Mechanisms;    Dynamic expression;    Chromatin state;    Transcription factor;    Specific DNA sequence;    microRNA;    Post-transcriptional regulation;   

DOI  :  10.2478/s11658-014-0212-6

学科分类：分子生物学，细胞生物学和基因

来源: Uniwersytet Wroclawski * Wydzial Biotechnologii / University of Wroclaw, Faculty of Biotechnology

【 摘 要 】

Long non-coding RNAs (lncRNAs) are series of transcripts with important biological functions. Various diseases have been associated with aberrant expression of lncRNAs and the related dysregulation of mRNAs. In this review, we highlight the mechanisms of dynamic lncRNA expression. The chromatin state contributes to the low and specific expression of lncRNAs. The transcription of non-coding RNA genes is regulated by many core transcription factors applied to protein-coding genes. However, specific DNA sequences may allow their unsynchronized transcription with their location-associated mRNAs. Additionally, there are multiple mechanisms involved in the post-transcriptional regulation of lncRNAs. Among these, microRNAs might have indispensible regulatory effects on lncRNAs, based on recent discoveries.

【 授权许可】

Unknown