Oncofetal antigen/immature laminin receptor protein in pregnancy and cancer

Cellular & Molecular Biology Letters

Adel L. Barsoum¹  Paul O. Schwarzenberger¹ 

[1] Department of Microbiology and Immunology, University of South Alabama, Mobile, USA$$Quantum Immunologics, Mobile, USA$$

关键词: Cancer;    Galectins;    Immature laminin receptor;    Oncofetal antigen;    Pregnancy;   

DOI  :  10.2478/s11658-014-0203-7

学科分类：分子生物学，细胞生物学和基因

来源: Uniwersytet Wroclawski * Wydzial Biotechnologii / University of Wroclaw, Faculty of Biotechnology

【 摘 要 】

The 37-kDa immature laminin receptor protein (iLRP) is a speciesconserved, universal immunogenic protein that is expressed in all thus-far examined embryonic and early fetal cells of inbred and outbred rodents. It has also been identified in human concepti. It is altered through normal maturation processes to become a non-immunogenic 67-kDa dimeric mature laminin receptor protein (mLRP) in mid-to late gestation in the mammalian fetus. This antigen ceases to be expressed as an active autoimmunogen in the full-term fetus and in the normal differentiating tissues and organs of the neonate or adult organism, apparently due to dimerization, but it is re-expressed as an immunogenic monomer in tumor cells. In this review, we highlight the known mechanisms of immune responses with particular emphasis on the possible role of the 37-kDa oncofetal antigen/immature laminin receptor (OFA/iLRP) in both pregnancy and cancer.

【 授权许可】

Unknown