Myricetin blocks lipoteichoic acid-induced COX-2 expression in human gingival fibroblasts

Cellular & Molecular Biology Letters

Cristina Hernández-Bermúdez¹  Juan Antonio Arreguín-Cano¹  Gloria Gutiérrez-Venegas¹  Oscar Alonso Luna¹ 

[1]Laboratorio de Bioquímica, División de Estudios de Posgrado e Investigación, Facultad de Odontología, Universidad Nacional Autónoma de México, Ciudad de México, México$$

关键词: Periodontitis;    Fisetin;    Morin;    Myricetin;    Luteolin;    Human gingival fibroblasts;    Lipoteichoic acid;    Cyclooxygenase;   

DOI  :  10.2478/s11658-014-0186-4

学科分类：分子生物学，细胞生物学和基因

来源: Uniwersytet Wroclawski * Wydzial Biotechnologii / University of Wroclaw, Faculty of Biotechnology

【 摘 要 】

Periodontitis is an infectious disease caused by microorganisms present in dental bacterial plaque. Lipoteichoic acid (LTA) is a component of the external membrane of Gram-positive bacteria. It causes septic shock. Ingested flavonoids have been reported to directly affect the regulation of cyclooxygenase-2 (COX-2) expression induced by bacterial toxins. In this study, we examined the effects of four flavonoids (luteolin, fisetin, morin and myricetin) on the activation of ERK1/2, p38 and AKT, and on the synthesis of COX-2 in human gingival fibroblasts treated with LTA from Streptococcus sanguinis. We found that luteolin and myricetin blocked AKT and p38 activation and that myricetin blocked LTA-induced COX-2 expression. The results of our study are important for elucidating the mechanism of action of flavonoid regulation of inflammatory responses.

【 授权许可】

Unknown