microRNAs: fine tuning of erythropoiesis

Cellular & Molecular Biology Letters

Elżbieta Heger¹  Beata Machnicka¹  Aleksander F. Sikorski³  Kazimierz Kuliczkowski²  Jacek Leluk¹  Dżamila M. Bogusławska¹  Marcin A. Listowski¹ 

[1] Department of Molecular Biology, University of Zielona, Góra, Poland$$;Department of Hematology, Medical University of Wrocław, Wrocław, Poland$$;Department of Molecular Biology, University of Zielona, Góra, Poland$$Laboratory of Cytobiochemistry, Faculty of Biotechnology, University of Wrocław, Wrocław, Poland$$

关键词: Hematopoiesis;    Erythrocyte;    Erythroid differentiation;    Erythropoiesis;    microRNA (miRNA);    microRNA expression;   

DOI  :  10.2478/s11658-012-0038-z

学科分类：分子生物学，细胞生物学和基因

来源: Uniwersytet Wroclawski * Wydzial Biotechnologii / University of Wroclaw, Faculty of Biotechnology

【 摘 要 】

Cell proliferation and differentiation is a complex process involving many cellular mechanisms. One of the best-studied phenomena in cell differentiation is erythrocyte development during hematopoiesis in vertebrates. In recent years, a new class of small, endogenous, non-coding RNAs called microRNAs (miRNAs) emerged as important regulators of gene expression at the post-transcriptional level. Thousands of miRNAs have been identified in various organisms, including protozoa, fungi, bacteria and viruses, proving that the regulatory miRNA pathway is conserved in evolution. There are many examples of miRNA-mediated regulation of gene expression in the processes of cell proliferation, differentiation and apoptosis, and in cancer genesis. Many of the collected data clearly show the dependence of the proteome of a cell on the qualitative and quantitative composition of endogenous miRNAs. Numerous specific miRNAs are present in the hematopoietic erythroid line. This review attempts to summarize the state of knowledge on the role of miRNAs in the regulation of different stages of erythropoiesis. Original experimental data and results obtained with bioinformatics tools were combined to elucidate the currently known regulatory network of miRNAs that guide the process of differentiation of red blood cells.

【 授权许可】

Unknown