Quantitative and dynamic expression profile of premature and active forms of the regional ADAM proteins during chicken brain development

Cellular & Molecular Biology Letters

Arndt Rolfs¹  Annett Markus¹  Xin Yan¹  Jiankai Luo¹ 

[1]Albrecht-Kossel-Institute for Neuroregeneration, Centre for Mental Health Disease, University of Rostock, Rostock, Germany$$

关键词: ADAM;    Gene expression;    Protein;    Brain development;    Chicken;   

DOI  :  10.2478/s11658-011-0016-x

学科分类：分子生物学，细胞生物学和基因

来源: Uniwersytet Wroclawski * Wydzial Biotechnologii / University of Wroclaw, Faculty of Biotechnology

【 摘 要 】

The ADAM (A Disintegrin and Metalloprotease) family of transmembrane proteins plays important roles in embryogenesis and tissue formation based on their multiple functional domains. In the present study, for the first time, the expression patterns of the premature and the active forms of six members of the ADAM proteins — ADAM9, ADAM10, ADAM12, ADAM17, ADAM22 and ADAM23 — in distinct parts of the developing chicken brain were investigated by quantitative Western blot analysis from embryonic incubation day (E) 10 to E20. The results show that the premature and the active forms of various ADAM proteins are spatiotemporally regulated in different parts of the brain during development, suggesting that the ADAMs play a very important role during embryonic development.

【 授权许可】

Unknown