The role of P63 in cancer, stem cells and cancer stem cells

Cellular & Molecular Biology Letters

Marta Nekulova²  Borivoj Vojtesek²  Jitka Holcakova²  Philip Coates¹ 

[1] Division of Medical Sciences, University of Dundee, Dundee, UK$$;Masaryk Memorial Cancer Institute, Brno, Czech Republic$$

关键词: p63;    TAp63;    ΔNp63;    p53 family;    Cancer;    Stem cells;   

DOI  :  10.2478/s11658-011-0009-9

学科分类：分子生物学，细胞生物学和基因

来源: Uniwersytet Wroclawski * Wydzial Biotechnologii / University of Wroclaw, Faculty of Biotechnology

【 摘 要 】

The transcription factor p63 has important functions in tumorigenesis, epidermal differentiation and stem cell self-renewal. The TP63 gene encodes multiple protein isoforms that have different or even antagonistic roles in these processes. The balance of p63 isoforms, together with the presence or absence of the other p53 family members, p73 and p53, has a striking biological impact. There is increasing evidence that interactions between p53-family members, whether cooperative or antagonistic, are involved in various cell processes. This review summarizes the current understanding of the role of p63 in tumorigenesis, metastasis, cell migration and senescence. In particular, recent data indicate important roles in adult stem cell and cancer stem cell regulation and in the response of cancer cells to therapy.

【 授权许可】

Unknown