Regulation of bacterial protease activity

Cellular & Molecular Biology Letters

Katarzyna Pustelny¹  Benedykt Władyka¹ 

[1] Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Kraków, Poland$$

关键词: Protease;    Protease inhibitor;    Zymogen;    Operon;   

DOI  :  10.2478/s11658-007-0048-4

学科分类：分子生物学，细胞生物学和基因

来源: Uniwersytet Wroclawski * Wydzial Biotechnologii / University of Wroclaw, Faculty of Biotechnology

【 摘 要 】

Proteases, also referred to as peptidases, are the enzymes that catalyse the hydrolysis of peptide bonds in polipeptides. A variety of biological functions and processes depend on their activity. Regardless of the organism’s complexity, peptidases are essential at every stage of life of every individual cell, since all protein molecules produced must be proteolytically processed and eventually recycled. Protease inhibitors play a crucial role in the required strict and multilevel control of the activity of proteases involved in processes conditioning both the physiological and pathophysiological functioning of an organism, as well as in host-pathogen interactions. This review describes the regulation of activity of bacterial proteases produced by dangerous human pathogens, focusing on the Staphylococcus genus.

【 授权许可】

Unknown