Orphan nuclear hormone receptor NR4A1 interacts with HPV16 E2 regulatory protein

Cellular & Molecular Biology Letters

Anna Goździcka-Józefiak³  Marcin T. Schmidt¹  Agnieszka K. Olejnik-Schmidt² 

[1] Department of Biotechnology and Food Microbiology, August Cieszkowski University of Agriculture, Poznań, Poland$$;Department of Biotechnology and Food Microbiology, August Cieszkowski University of Agriculture, Poznań, Poland$$Department of Molecular Virology, Adam Mickiewicz University, Poznań, Poland$$;Department of Molecular Virology, Adam Mickiewicz University, Poznań, Poland$$

关键词: NR4A1;    Nur77;    E2;    HPV16;    Two-hybrid system;    Nuclear localization;    Colocalization studies;   

DOI  :  10.2478/s11658-006-0010-x

学科分类：分子生物学，细胞生物学和基因

来源: Uniwersytet Wroclawski * Wydzial Biotechnologii / University of Wroclaw, Faculty of Biotechnology

【 摘 要 】

The human NR4A1 orphan receptor is a member of the TR3 steroid receptor superfamily, which binds DNA at the NBRE and NurRE responsive elements. The TR3 receptors are involved in the regulation of differentiation, proliferation and apoptosis. We report that NR4A1 interacts with human papillomavirus type 16 (HPV16) E2 protein — a key papillomavirus regulatory factor. This interaction might be involved in the transcription regulation of the HPV16 genes and the regulation of infected cell homeostasis.

【 授权许可】

Unknown