Association of MYH9 Polymorphisms with Hypertension in Patients with Chronic Kidney Disease in China

Kidney and Blood Pressure Research

Caili Wang¹  Lei Nan¹  Dan Liu¹  Liping Liu¹  Yan Mi¹  Yu Du¹  Junying Fan¹  Li Li¹  Niya Jia¹ 

[1] Division of Nephrology, The First Affiliated Clinical Hospital of Baotou Medical College, Baotou, China$$

关键词: Chronic kidney disease;    Hypertension;    MYH9;    Polymorphism;    Systolic blood pressure;   

DOI  :  10.1159/000452597

来源: S Karger AG

【 摘 要 】

Background/Aims: This study explored the correlation between hypertension and non-muscle myosin heavy chain 9 (MYH9) gene polymorphisms in Chinese chronic kidney disease (CKD) patients. Methods: This case-control study included 301 patients with CKD and 293 healthy controls. The E1 haplotype single nucleotide polymorphisms (SNPs) rs3752462 and rs4821480 were genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis. The association between MYH9 polymorphisms and high systolic blood pressure (SBP ≥ 140 mmHg) susceptibility in CKD patients was analysed. Results: The cases and controls had similar genotype and allele distributions at rs3752462 and rs4821480. No GG genotype at rs4821480 was observed. Patients with SBP < 140 mmHg were more likely to have the CC genotype (17.1%) than patients with SBP ≥ 140 mmHg (4.3%) (P = 0.001). Creatinine clearance (OR = 0.99, 95% CI = 0.98-0.10, P = 0.01) was associated with SBP in patients with CKD. The risk of SBP ≥ 140 mmHg was 0.24-fold greater among patients with the CC genotype than among patients with the TT genotype (P = 0.002). Conclusion: The rs3752462 polymorphism of MYH9 is associated with SBP in patients with CKD. The T allele in the dominant model was associated with an elevated risk for high SBP.

【 授权许可】

Unknown