Depression and Quality of Life in Relation to Decreased Glomerular Filtration Rate Among Adults with Hypertension in Rural Northeast China

Kidney and Blood Pressure Research

Yu S.³  Li Z.³  Zhu L.¹  Guo L.³  Zheng L.²  Yang H.³  Sun Y.³  Zhang Y.²  Guo X.³ 

[1] Department of Cardiology, Dongfang Hospital affiliated to Tongji University, Shanghai; $$;Department of Cardiology, the First Hospital of China Medical University; $$

关键词: Chronic kidney disease;    Depression;    Glomerular filtration rate;    Hypertension quality of life;   

DOI  :  10.1159/000368480

来源: S Karger AG

【 摘 要 】

Background/Aims: We aim to investigate the extent to which depression and quality of life might be associated with decreased glomerular filtration rate (GFR) in a large hypertensive population in rural Northeast China. Methods: A total of 5566 hypertensive participants aged 35 years and older were screened with a stratified cluster multistage sampling scheme in rural areas of Liaoning Province during 2012-2013. Decreased GFR was defined as estimated GFR <60 ml/min/1.73 m². Results: The overall prevalence of decreased GFR was 3.2%. In the multivariable regression model, participants with moderate or greater depression had a greater risk for having a decreased GFR (OR: 1.739, 95%CI: 1.004 to 3.014) after full adjustment. Every 1-point increase of all the domains in WHOQOL-BREF, except for physical and environment domains, was significantly related to a lower risk for decreased GFR adjusting for age, gender and race. However, after fully adjustment, only social relations remained significant (OR: 0.899, 95%CI: 0.820 to 0.985). Increasing in total scores of WHOQOL-BREF was a protective factor against decreased GFR after fully adjustment. Conclusion: We found that moderate or greater depression and lower quality of life were associated with higher risks for developing decreased GFR.

【 授权许可】

Unknown