Development and evaluation of an optical fibre-based helium–neon laser irradiation system for tissue regeneration: A pilot study

Pramana

B Satish Shenoy²  K K Mahato1³  B Nageshwara Rao¹  B S Satish Rao¹  Vijendra Prabhu³  B Kiran Aithal¹ 

[1] Division of Radiobiology and Toxicology, Manipal University, Manipal 576 104, India$$;Department of Mechanical and Manufacturing Engineering, Manipal Institute of Technology, Manipal University, Manipal 576 104, India$$;Biophysics Unit, Manipal Life Sciences Centre, Manipal University, Manipal 576 104, India$$

关键词: Therapeutic application;    optimization;    tissue response;    contraction.;   

DOI  :  

学科分类：物理（综合）

来源: Indian Academy of Sciences

【 摘 要 】

Low level laser therapy is being extensively used to treat various medical ailments including wound healing. In the present study, an optical fibre-based helium–neon (He–Ne) laser irradiation system was designed, developed and evaluated for optimum tissue repair on mice excision wounds. Circular wounds of 15 mm diameter were created on the dorsum of animals and single exposure of uniformly distributed laser beam was administered at 1, 2 and 3 J/cm2 to the respective test groups with suitable controls. Progression of healing was monitored by measuring wound contraction and mean healing time. Significant reduction in wound size and mean healing time (𝑝 < 0.001) were observed in the test groups for the laser dose of 2 J/cm2 compared to the unilluminated controls, suggesting the suitability of this dose.

【 授权许可】

Unknown