Pramana | |
Statistical mechanics of thermal denaturation of DNA oligomers | |
Navin Singh11  Yashwant Singh11  | |
[1] Department of Physics, Banaras Hindu University, Varanasi 221 005, India$$ | |
关键词: DNA; elasticity; defect; denaturation.; | |
DOI : | |
学科分类:物理(综合) | |
来源: Indian Academy of Sciences | |
【 摘 要 】
Double stranded DNA chain is known to have non-trivial elasticity. We study the effect of this elasticity on the denaturation proï¬le of DNA oligomer by constraining one base pair at one end of the oligomer to remain in unstretched (or intact) state. The effect of this constraint on the denaturation proï¬le of the oligomer has been calculated using the Peyrard–Bishop Hamiltonian. The denaturation proï¬le is found to be very different from the free (i.e. without the constraint) oligomer. We have also examined how this constraint affects the denaturation proï¬le of the oligomer having a segment of defect sites located at different parts of the chain.
【 授权许可】
Unknown
【 预 览 】
Files | Size | Format | View |
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RO201912040496363ZK.pdf | 93KB | download |