Immune modulation by dendritic-cell-based cancer vaccines

Journal of biosciences

MINISH JAIN⁴  SAKSHI KOHLI²  ASHOK KUMAR VAID¹  CHAITANYA KUMAR1²  VENKATA SATHYA SURESH ATTILI³  BANDANA SHARAN²  POONAMALLE PARTHASARATHY BAPSY⁵ 

[1] Medanta, Gurgaon, India$$;APAC Biotech Pvt Ltd, Gurgaon, India$$;Apollo Hospital, Hyderabad, India$$;Ruby Hall Clinic, Pune, India$$;Department of Oncology, Apollo Hospital, Bengaluru, India$$

关键词: Cancer immunotherapy;    dendritic cell;    tumour immunity;   

DOI  :  

来源: Indian Academy of Sciences

【 摘 要 】

The interplay between host immunity and tumour cells has opened the possibility of targeting tumour cells bymodulation of the human immune system. Cancer immunotherapy involves the treatment of a tumour by utilizing therecombinant human immune system components to target the pro-tumour microenvironment or by revitalizing theimmune system with the ability to kill tumour cells by priming the immune cells with tumour antigens. In this review,current immunotherapy approaches to cancer with special focus on dendritic cell (DC)-based cancer vaccines arediscussed. Some of the DC-based vaccines under clinical trials for various cancer types are highlighted. Establishingtumour immunity involves a plethora of immune components and pathways; hence, combining chemotherapy,radiation therapy and various arms of immunotherapy, after analysing the benefits of individual therapeutic agents,might be beneficial to the patient.

【 授权许可】

Unknown