Brain-derived neurotrophic factor and early-life stress: Multifaceted interplay

Journal of biosciences

TATIANA I MERKULOVA¹  NATALYA P BONDAR1¹ 

[1] Laboratory of Gene Expression Regulation, Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, Novosibirsk, Russia$$

关键词: BDNF;    early-life stress;    epigenetic regulation;    maternal separation;   

DOI  :  

来源: Indian Academy of Sciences

【 摘 要 】

The brain-derived neurotrophic factor (BDNF) is a key regulator of neural development and plasticity. Longtermchanges in the BDNF pathway are associated with childhood adversity and adult depression symptoms.Initially, stress-induced decreases in the BDNF pathway were found in some studies, but subsequent reportsindicated the relationship between stress and BDNF to be much more complex, and the concept wassignificantly revised. In the present mini-review, we focus on the structure and regulation of the Bbnf geneas well as on the stress–BDNF interactions under early-life adverse conditions.

【 授权许可】

Unknown