Triphala, a formulation of traditional Ayurvedic medicine, shows protective effect against X-radiation in HeLa cells

Journal of biosciences

MOHAMMAD NAZIR HOSSAIN²  MASATAKE YAMAUCHI³  DAI AYUSAWA¹  KENSUKE MIKI¹  JUMA MITA¹  MITOMU KIOI⁴  YUKI TAKAUJI¹  MICHIHIKO FUJII1¹ 

[1] Graduate School of Nanobioscience, Yokohama City University, Kanagawa 236-0027, Japan$$;Department of Biochemistry, Primeasia University, Dhaka 1213, Bangladesh$$;National Institute of Radiological Sciences, Chiba 263-8555, Japan$$;Yokohama City University Graduate School of Medicine, Kanagawa 236-0008, Japan$$

关键词: Ayurveda;    bleomycin;    reactive oxygen species;    Triphala;    X-radiation;   

DOI  :  

来源: Indian Academy of Sciences

【 摘 要 】

Ayurveda is a holistic medical system of traditional medicine, and Triphala is one of the most popular formulations inAyurveda. Triphala is composed of three kinds of herb, Terminalia chebula, Terminalia bellirica, and Emblicaofficinalis. Since Triphala is shown to exhibit a protective activity against ionizing radiation in mice, we investigatedits activity in HeLa cells. We found that Triphala showed the protective effects against X-radiation and bleomycin,both of which generate DNA strand breaks, in HeLa cells. Further, Triphala efficiently eliminated reactive oxygenspecies (ROS) in HeLa cells. Thus, the antioxidant activity of Triphala would likely play a role in its protective actionsagainst X-radiation and bleomycin because both agents damage DNA through the generation of ROS. Theseobservations suggested that the radioprotective activity of Triphala can be, at least partly, studied with the cellscultured in vitro. The simple bioassay system with human cultured cells would facilitate the understanding of themolecular basis for the beneficial effects of Triphala.

【 授权许可】

Unknown