Impact of the PPAR gamma-2 gene polymorphisms on the metabolic state of postmenopausal women

Journal of biosciences

BOGNA GRYGIEL-GÓRNIAK1 2¹  JERZY NOWAK¹  MARIA MOSOR³  JULIUSZ PRZYSŁAWSKI¹  JUSTYNA MARCINKOWSKA² 

[1] Department of Bromatology and Human Nutrition, Poznan University of Medical Sciences, Poznan, Poland$$;Department of Computer Science and Statistics, Poznan University of Medical Sciences, Poznan, Poland$$;Department of Molecular Pathology, Institute of Human Genetics, Polish Academy of Sciences, Poznan, Poland$$

关键词: Metabolic disorders;    obesity;    polymorphisms;   

DOI  :  

来源: Indian Academy of Sciences

【 摘 要 】

The relationship Pro12Ala (rs1801282) and C1431T (rs3856806) polymorphisms of PPAR gamma-2 with glucose and lipid metabolism is not clear after menopause. We investigated the impact of the Pro12Ala and C1431T silentsubstitution in the 6th exon in PPAR gamma-2 gene on nutritional and metabolic status in 271 postmenopausal women(122 lean and 149 obese). The general linear model (GLM) approach to the two-way analysis of variance (ANOVA) was used to infer the interactions between the analysed genotypes. The frequency of the Pro-T haplotype was higher in obese than in lean women ($plt 0.0349$). In the analysed GLM models according to obesity status, the C1431C genotypewas related to a lower glucose concentration ($eta=-0.2103$) in lean women, and to higher folliculotropic hormone FSH levels ($eta=0.1985$) and lower waist circumferences ($eta=-0.1511$) in obese women. The influence of C1431C waspresent regardless of the occurrence of the Pro12Ala polymorphism. The co-existence of the C1431C and Pro12Progenotypes was related to lower values for triceps skinfold thickness compared those for the T1241/X and Ala12/X polymorphisms ($eta=-0.1425$). The presence of C1431C decreased the differences between triceps values that weredetermined by Pro or Ala allele. In conclusion, C1431T polymorphism seems to have a more essential influence onanthropometric and biochemical parameters than is the case with Pro12Ala polymorphism.

【 授权许可】

Unknown