Bifidogenic effect of grain larvae extract on serum lipid, glucose and intestinal microflora in rats

Journal of biosciences

Sang-Oh Park²  Byung-Sung Park2¹ 

[1] Division of Applied Animal Science, Kangwon National University, Chuncheon, Gangwondo 200-701, Korea$$;Institute of Animal Resources, Kangwon National University, Chuncheon, Gangwondo 200-701, Korea$$

关键词: Bifidogenic effect;    blood lipid;    cecal microflora;    grain larvae;    IgG;    organic acid;   

DOI  :  

来源: Indian Academy of Sciences

【 摘 要 】

The main objective of this study was to investigate whether orally administered Korean grain larvae ethanol extract (GLE) had a bifidogenic effect in normal rats. Male Sprague–Dawley rats were divided into a negative control group (CO) and GLE orally administered (5.0, 7.0 and 9.0 mg/100 g body weight) groups. Thymus and spleen weights dosedependently increased by 128.58% and 128.58%, respectively, but abdominal fat decreased by 19.18% after GLE administration compared with that in the CO group (𝑝<0.05). Serum triglycerides, total cholesterol, low-density lipoprotein cholesterol, and glucose decreased by 30.26%, 7.33%, 27.20%, and 6.96%, respectively, whereas highdensity lipoprotein cholesterol increased by 129.93% in the GLE groups compared with those in the CO group (𝑝<0.05). IgG, IgM, IgA in the GLE groups increased 203.68%, 181.41%, and 238.25%, respectively, compared to that in the CO group (𝑝<0.05). Bifidobacteria and Lactobacillus increased by 115.74% and 144.28%, whereas Bacteroides, Clostridium, Escherichia, and Streptococcus decreased by 17.37%, 17.46%, 21.25%, and 19.16%, respectively, in the GLE groups compared with those in the CO group (𝑝<0.05). Total organic acids, acetic acid, and propionic acid increased by 151.40%, 188.09%, and 150.17%, whereas butyric acid and valeric acid decreased by 40.65% and 49.24%, respectively, in the GLE groups as compared with those in the CO group (𝑝<0.05). These results suggest that Korean GLE improves the bifidogenic effect by increasing cecal organic acids and modulating gut microflora via a selective increase in Bifidobacterium in normal rats.

【 授权许可】

Unknown