Prooxidative effects of aspartame on antioxidant defense status in erythrocytes of rats

Journal of biosciences

Branka I Ognjanović2²  AndraÅ¡ Å  Å tajn²  Milica G Paunović²  MiloÅ¡ M Matić²  NataÅ¡a Z Djordjević¹ 

[1] Department of Biomedical Sciences, State University of Novi Pazar, Vuka Karadžića bb 36300 Novi Pazar, Serbia$$;Institute of Biology and Ecology, Faculty of Science, University of Kragujevac, Radoja Domanovića 12, 34000 Kragujevac, Serbia$$

关键词: Antioxidative defense system;    aspartame;    erythrocytes;    oxidative stress;    rat;   

DOI  :  

来源: Indian Academy of Sciences

【 摘 要 】

Since aspartame (L-aspartyl-L-phenylalanine methyl ester, ASP) is one of the most widely used artificial sweeteners, the aim of the present study was to investigate its effects on serum glucose and lipid levels as well as its effects on oxidative/antioxidative status in erythrocytes of rats. The experiment included two groups of animals: the control group was administered with water only, while the experimental group was orally administered with ASP (40 mg/kg b.w.) daily, for a period of six weeks. When compared with the control group, the group administrated with ASP indicated higher values of serum glucose, cholesterol and triglycerides. Significantly increased concentrations of superoxide anion (O2•−), hydrogen peroxide (H2O2), peroxynitrite (ОNОО−) and lipid peroxides (LPO) were recorded in the erythrocytes of ASP treated group in comparison to the control group. In the course of chronic ASP administration, the following was observed: the concentration of reduced glutathione (GSH) and the activity of catalase (CAT) increased. Thus, these findings suggest that long-term consumption of ASP leads to hyperglycemia and hyperlipidemia, as well as to oxidative stress in erythrocytes.

【 授权许可】

Unknown