Modelling the transition from simple to complex Ca2+ oscillations in pancreatic acinar cells

Journal of biosciences

K R Pardasani¹  Neeraj Manhas1¹  James Sneyd² 

[1]Department of Mathematics, Maulana Azad National Institute of Technology, Bhopal 462 051, India$$

[2]Department of Mathematics, University of Auckland, Private Bag 92019, Auckland, New Zealand$$

关键词: [IP3];    calcium oscillations;    chaos;    FFT;    IPR;    pancreatic acinar cells;    RyR;   

DOI  :  

来源: Indian Academy of Sciences

【 摘 要 】

A mathematical model is proposed which systematically investigates complex calcium oscillations in pancreatic acinar cells. This model is based on calcium-induced calcium release via inositol trisphosphate receptors (IPR) and ryanodine receptors (RyR) and includes calcium modulation of inositol (1,4,5) trisphosphate (IP3) levels through feedback regulation of degradation and production. In our model, the apical and the basal regions are separated by a region containing mitochondria, which is capable of restricting Ca2+ responses to the apical region. We were able to reproduce the observed oscillatory patterns, from baseline spikes to sinusoidal oscillations. The model predicts that calcium-dependent production and degradation of IP3 is a key mechanism for complex calcium oscillations in pancreatic acinar cells. A partial bifurcation analysis is performed which explores the dynamic behaviour of the model in both apical and basal regions.

【 授权许可】

Unknown