In vitro and in vivo neurogenic potential of mesenchymal stem cells isolated from different sources

Journal of biosciences

John P John¹  Rajarshi Pal²  Ramesh Bhonde²  MamidiMurali Krishna²  Gurbind Singh⁵  Ramyani Taran²  Anjan Kumar Das7³  Susmita Dutta⁴  Ishwar S Parhar⁶ 

[1]Multimodal Brain Image Analysis Laboratory (MBIAL), National Institute of Mental Health and Neurosciences (NIMHANS), Bangalore, India$$

[2]Manipal Institute of Regenerative Medicine, Manipal University Branch Campus, Bangalore, India$$

[3]Department of Surgery, Taylor's University Clinical School, Sungai Buloh Hospital, Selangor, Malaysia$$

[4]Department of Anesthesiology, Taylor’s University Clinical School, Sungai Buloh Hospital, Selangor, Malaysia$$

[5]Stempeutics Research Malaysia Sdn. Bhd, Technology Park Malaysia, 57000 Kuala Lumpur, Malaysia$$

[6]Brain Research Institute, Jeffrey Cheah School of Medicine and Health Sciences, Monash University Sunway Campus, Jalan Lagoon Selatan, 46150 Bandar Sunway, Selangor, Malaysia$$

关键词: Clinical trials;    mesenchymal stem cells (MSCs);    neuronal differentiation;    self-renewal;   

DOI  :  

来源: Indian Academy of Sciences

【 摘 要 】

Regenerative medicine is an evolving interdisciplinary topic of research involving numerous technological methods that utilize stem cells to repair damaged tissues. Particularly, mesenchymal stem cells (MSCs) are a great tool in regenerative medicine because of their lack of tumorogenicity, immunogenicity and ability to perform immunomodulatory as well as anti-inflammatory functions. Numerous studies have investigated the role of MSCs in tissue repair and modulation of allogeneic immune responses. MSCs derived from different sources hold unique regenerative potential as they are self-renewing and can differentiate into chondrocytes, osteoblasts, adipocytes, cardiomyocytes, hepatocytes, endothelial and neuronal cells, among which neuronal-like cells have gained special interest. MSCs also have the ability to secrete multiple bioactive molecules capable of stimulating recovery of injured cells and inhibiting inflammation. In this review we focus on neural differentiation potential ofMSCs isolated from different sources and how certain growth factors/small molecules can be used to derive neuronal phenotypes from MSCs. We also discuss the efficacy of MSCs when transplanted in vivo and how they can generate certain neurons and lead to relief or recovery of the diseased condition. Furthermore, we have tried to evaluate the appropriatemerits of different sources of MSCs with respect to their propensity towards neurological differentiation as well as their effectiveness in preclinical studies.

【 授权许可】

Unknown