Maternal hormonal interventions as a risk factor for Autism Spectrum Disorder: An epidemiological assessment from India

Journal of biosciences

Vidya Rajesh1⁴  Anupama Polinedi⁴  Nidhi Singhal³  Omsai Ramesh Vallamkonda¹  V Rajesh Udani²  N Rajesh⁵  Madhu Poornima Mamidala⁴  P T V Praveen Kumar⁶ 

[1] Department of Medical Sciences, National Institute for the Mentally Handicapped (NIMH), Manovikasnagar, Secunderabad 500 009, India$$;Child Neurology and Epilepsy, P.D. Hinduja National Hospital and Medical Research Centre, Veer Savarkar Marg, Mahim, Mumbai 400 016, India$$;Action For Autism (AFA), The National Centre for Autism, Pocket 7 and 8 Jasola Vihar, New Delhi 110 025, India$$;Department of Biological Sciences, Birla Institute of Technology and Science, Pilani – Hyderabad Campus, Jawaharnagar, Shamirpet (M), Hyderabad 500 078, India$$;Department of Chemistry, Birla Institute of Technology and Science, Pilani – Hyderabad Campus, Jawaharnagar, Shamirpet (M), Hyderabad 500 078, India$$;Department of Mathematics, Birla Institute of Technology and Science, Pilani – Hyderabad Campus, Jawaharnagar, Shamirpet (M), Hyderabad 500 078, India$$

关键词: Autism Spectrum Disorder;    India;    infertility;    hormonal interventions;    risk factors;   

DOI  :  

来源: Indian Academy of Sciences

【 摘 要 】

Globalization and women empowerment have led to stressful life among Indian women. This stress impairs women’s hormonal makeup and menstrual cycle, leading to infertility. National Family Health Survey-3 (NFHS-3) reports a decline in fertility status in India, indicating a rise in various infertility treatments involving hormonal interventions. No studies are available from India on the risk association link between maternal hormonal treatments and ASD. Hence, this study explores the association of maternal hormonal interventions with risk for ASD. Parents of 942 children (471 ASD and 471 controls) across 9 cities in India participated in the questionnaire-based study. The questionnaire was pilot tested and validated for its content and reliability as a psychometric instrument. Data collection was done at 70 centres through direct interaction with parents and with the help of trained staff. Statistical analysis of data was carried out using SAS 9.1.3. Out of the 471 ASD cases analysed, 58 mothers had undergone hormonal interventions (12.3%) while there were only 22 mothers among controls who underwent hormonal interventions (4.6%). According to logistic regression analysis maternal hormonal intervention (OR=2.24) was a significant risk factor for ASD.

【 授权许可】

Unknown