Production of paclitaxel by Fusarium solani isolated from Taxus celebica

Journal of biosciences

Anjali A Karande¹  B V S K Chakravarthi¹  Prasanta Das²  Kalpana Surendranath¹  Chelliah Jayabaskaran1¹ 

[1] Department of Biochemistry, Indian Institute of Science, Bangalore 560 012, India$$;Department of Inorganic and Physical Chemistry, Indian Institute of Science, Bangalore 560 012, India$$

关键词: Apoptosis;    endophytic fungus;    Fusarium solani;    paclitaxel;   

DOI  :  

来源: Indian Academy of Sciences

【 摘 要 】

A fungus was isolated from the stem cuttings of Taxus celebica, which produced paclitaxel in liquid-grown cultures. The fungus was identified as Fusarium solani based on colony characteristics, morphology of conidia and the 26S rDNA sequence. Paclitaxel was identified by chromatographic and spectroscopic comparison with authentic paclitaxel and its cytotoxic activity towards Jurkat cells in vitro.

【 授权许可】

Unknown