Homing of radiolabelled recombinant interleukin-2 activated natural killer cells and their efficacy in adoptive immunotherapy against murine fibrosarcoma

Journal of biosciences

Ashim K Chakravarty¹  Anuradha Rai1² 

[1] Centre for Life Sciences, North Bengal University, Siliguri 734 430, India$$;Department of Zoology, St Joseph's College, Darjeeling 734 104, India$$

关键词: Adoptive immunotherapy;    ascitic fibrosarcoma;    natural killer cells;    non-recurrence of tumour;    recombinant interleukin-2 activation;   

DOI  :  

来源: Indian Academy of Sciences

【 摘 要 】

Natural killer (NK) cells are spontaneously cytotoxic against tumour target cells. Their number was found to be four times more in the spleen of tumour-bearing Swiss albino mice. After activation with recombinant interleukin-2 (rIL-2), NK cells were tested and found to seek out the tumour site when injected intravenously in tumour-bearing mice. Their potential for fighting tumours in vivo was further seen following adoptive transfer of rIL-2 activated NK (A-NK) cells in tumour-bearing mice. After surgical removal of tumour load, adoptive transfer of A-NK cells inhibited tumour recurrence in 92.3% cases, thereby suggesting the use of this protocol for therapeutic purposes to obtain a better outcome.

【 授权许可】

Unknown