Selenium acts as an insulin-like molecule for the down-regulation of diabetic symptoms via endoplasmic reticulum stress and insulin signalling proteins in diabetes-induced non-obese diabetic mice

Journal of biosciences

Jungsik Cho³  Sang-Koo Lee¹  Byeongcheol Kang²  Mikyong Jang³  Sunbo Shim³  Suhae Lee³  Minsun Kim³  Sujin Seo³  Daeyoun Hwang1³  Suyoun Yim³  Chuelkyu Kim³  Yongkyu Kim³  Insurk Jang⁴  Seungwan Jee³ 

[1] Sel-treated mice had significantly decreased serum biochemical components associated with liver damage and lipid metabolism,$$;Sel treatment led to the activation of the ER stress signal through the phosphorylation of JNK and eIF2 protein and insulin signal mechanisms through the phosphorylation of Akt and PI3 kinase, and$$;Sel treatment induced insulin-like effects in lowering serum glucose level in Sel-treated NOD mice,$$;Sel-treated mice were significantly relieved apoptosis of liver tissues indicated by DNA fragmentation assay in the diabetic NOD group.$$

关键词: Selenium;    ER stress;    insulin signal;    NOD;    lipid metabolism;    apoptosis;   

DOI  :  

来源: Indian Academy of Sciences

【 摘 要 】

To investigate whether selenium (Sel) treatment would impact on the onset of diabetes, we examined serum biochemical components including glucose and insulin, endoplasmic reticulum (ER) stress and insulin signalling proteins, hepatic C/EBP-homologous protein (CHOP) expression and DNA fragmentation in diabetic and non-diabetic conditions of non-obese diabetic (NOD) mice. We conclude thatSel treatment induced insulin-like effects in lowering serum glucose level in Sel-treated NOD mice,

【 授权许可】

Unknown