Host-pathogen interactions during apoptosis

Journal of biosciences

Rasheeda Begum³  Nand K Sah⁴  M Athar⁵  M Krishnaveni²  E M Shajil³  Sudhir Sahdev²  K V A Ramaiah¹  Seyed E Hasnain1 2 3²  Manjari Mohan⁴  Tarvinder K Taneja⁴ 

[1] Department of Biochemistry, University of Hyderabad, Hyderabad 500 046, India$$;Laboratory of Molecular and Cellular Biology, Centre for DNA Fingerprinting and Diagnostics, Hyderabad 500 076, India$$;Department of Biochemistry, M S University of Baroda, Vadodara 390 002, India$$;Eukaryotic Gene Expression Lab, National Institute of Immunology, New Delhi 110 076, India$$;Department of Medical Elementology and Toxicology, Jamia Hamdard, Hamdard Nagar , New Delhi, 110 062, India$$

关键词: Antioxidant;    baculovirus;    host-pathogen;    eIF2𝛼-kinase;    P35;    PKR;   

DOI  :  

来源: Indian Academy of Sciences

【 摘 要 】

Host pathogen interaction results in a variety of responses, which include phagocytosis of the pathogen, release of cytokines, secretion of toxins, as well as production of reactive oxygen species (ROS). Recent studies have shown that many pathogens exert control on the processes that regulate apoptosis in the host. The induction of apoptosis upon infection results from a complex interaction of parasite proteins with cellular host proteins. Abrogation of host cell apoptosis is often beneficial for the pathogen and results in a successful host invasion. However, in some cases, it has been shown that induction of apoptosis in the infected cells significantly imparts protection to the host from the pathogen. There is a strong correlation between apoptosis and the host protein translation machinery: the pathogen makes all possible efforts to modify this process so as to inhibit cell suicide and ensure that it can survive and, in some cases, establish latent infection. This review discusses the significance of various pathways/steps during virus-mediated modulation of host cell apoptosis.

【 授权许可】

Unknown