Regulatory mechanisms of viral hepatitis B and C

Journal of biosciences

G Waris¹  A Siddiqui1¹ 

[1] Department of Microbiology, Program in Molecular Biology, University of Colorado Health Sciences Center, 4200 E, 9th Ave, Denver, Colorado 80262, USA$$

关键词: ER stress;    hepatitis B virus;    hepatitis C virus;    NF-κB;    oxidative stress;    STAT-3;   

DOI  :  

来源: Indian Academy of Sciences

【 摘 要 】

Of all the hepatitis viruses, only the hepatitis B virus (HBV) and hepatitis C virus (HCV) cause chronic hepatitis, which can progress to cirrhosis and hepatocellular carcinoma. In this review, we discuss how these two biologically diverse viruses use common pathways to induce oxidative stress and activation of key transcription factors, known to be involved in inflammatory processes in cells. Activation of NF-𝜅B and STAT-3 most likely contribute to the progression of viral infections to chronic hepatitis and liver oncogenesis associated with HBV and HCV infections. In this review, we focus on the mechanisms of action of HBx and HCV NS5A proteins in inducing intracellular events associated with the viral infections.

【 授权许可】

Unknown