Effect of matrix metalloproteinase promoter polymorphisms on endometriosis and adenomyosis risk: evidence from a meta-analysis

Journal of genetics

JIARONG WANG²  YIQI ZHAO²  YAZHOU HE²  ZHU LAN²  HUI YE²  MINGRONG XI2¹  TIANGE SONG² 

[1] Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu 610041, People’s Republic of Chin$$;West China School of Medicine/West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, People’s Republic of Chin$$

关键词: matrix metalloproteinase gene;    polymorphism;    endometriosis;    adenomyosis;    meta-analysis.;   

DOI  :  

学科分类：生物科学（综合）

来源: Indian Academy of Sciences

【 摘 要 】

Matrix metalloproteinase (MMP) promoter polymorphisms are considered to play roles in the aetiology of endometriosis and adenomyosis, however, the evidence available are inconsistent. We aimed to systematically review the asscociationbetween MMP-1 -1607 1G/2G MMP-2 -735 C/T, MMP-3 -1171 5A/6A and MMP-9 -1562 C/T polymorphisms and the risk of endometriosis and adenomyosis. A systemic search was conducted in Ovid, PubMed, Chinese National Knowledge Infrastructure and Chinese Wanfang Database. We used the pooled odds ratio (OR) and their corresponding 95% confidence interval (CI) to calculate the statistical power. Besides, we evaluated the quality of individual studies based on Newcastle–Ottawa scale. A total of 13 papers with 18 studies conformed to our inclusion criteria. We observed a significant association betweenMMP-1 -1607 1G/2G polymorphism and the susceptibility of endometriosis and adenomyosis under recessive model (OR =1.25, 95%CI = 1.03–1.53,P=0.03). While no significant association was found in MMP-2 -735 C/T, MMP-3 -1171 5A/6A and MMP-9 -1562 C/T polymorphisms. This systemic review and meta-analysis suggested that the MMP-1 -1607 1G/2G polymorphism might play an important role in the risk of endometriosis and adenomyosis. Further, more well-designed and large-scale studies regarding gene–gene and gene–environment interactions are needed in the future.

【 授权许可】

Unknown