期刊论文详细信息
Journal of genetics
Polymorphisms in human DNA repair genes and head and neck squamous cell carcinoma
Ahmed Rebai1  Amel Hamza-Chaffai2  Rim Khlifi1 22 
[1] Bioinformatics Unit, Centre de Biotechnologie de Sfax, P. O. Box 1177, 3018 Sfax, Tunisia$$;Marine Ecotoxicology, UR 09-03, Sfax University, IPEIS, BP 805-3018 Sfax, Tunisia$$
关键词: head and neck squamous cell carcinoma;    XRCC1 gene;    ERCC2 (XPD) gene;    XRCC3 gene.;   
DOI  :  
学科分类:生物科学(综合)
来源: Indian Academy of Sciences
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【 摘 要 】

Genetic polymorphisms in some DNA repair proteins are associated with a number of malignant transformations like head and neck squamous cell carcinoma (HNSCC). Xeroderma pigmentosum group D (XPD) and X-ray repair cross-complementing proteins 1 (XRCC1) and 3 (XRCC3) genes are involved in DNA repair and were found to be associated with HNSCC in numerous studies. To establish our overall understanding of possible relationships between DNA repair gene polymorphisms and development of HNSCC, we surveyed the literature on epidemiological studies that assessed potential associations with HNSCC risk in terms of gene–environment interactions, genotype-induced functional defects in enzyme activity and/or protein expression, and the influence of ethnic origin on these associations.We conclude that large, well-designed studies of common polymorphisms in DNA repair genes are needed. Such studies may benefit from analysis of multiple genes or polymorphisms and from the consideration of relevant exposures that may influence the likelihood of HNSCC when DNA repair capacity is reduced.

【 授权许可】

Unknown   

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