A new strategy for estimating two-locus recombination fractions under some natural inequality restrictions

Journal of genetics

Xiaona Sheng²  Weijun Ma¹  Huakun Wang¹  Ying Zhou1¹ 

[1] School of Mathematical Sciences, Heilongjiang University, Harbin 150080, People’s Republic of China$$;School of Science, Harbin University, Harbin 150086, People’s Republic of China$$

关键词: constrained parameter problems;    linkage analysis;    restricted projection algorithm;    recombination fraction.;   

DOI  :  

学科分类：生物科学（综合）

来源: Indian Academy of Sciences

【 摘 要 】

Linkage analysis is now being widely used to map markers on each chromosome in the human genome, to map genetic diseases, and to identify genetic forms of common diseases. Two-locus linkage analysis and multi-locus analysis have been investigated comprehensively, and many computer programs have been developed to perform linkage analysis. Yet there exists a shortcoming in traditional methods, i.e., the parameter space of two-locus recombination fractions has not been emphasized sufficiently in the usual analyses. In this paper, we propose a new strategy for estimating the two-locus recombination fractions based on data of backcross family in the framework of some natural and necessary parameter restrictions. The new strategy is based on a restricted projection algorithm, which can provide fast reasonable estimates of recombination fraction, and can therefore serve as a superior alternative algorithm. Results obtained from both real and simulated data indicate that the new algorithm performs well in the estimation of recombination fractions and outperforms current methods.

【 授权许可】

Unknown