Journal of genetics | |
A new strategy for estimating two-locus recombination fractions under some natural inequality restrictions | |
Xiaona Sheng2  Weijun Ma1  Huakun Wang1  Ying Zhou11  | |
[1] School of Mathematical Sciences, Heilongjiang University, Harbin 150080, People’s Republic of China$$;School of Science, Harbin University, Harbin 150086, People’s Republic of China$$ | |
关键词: constrained parameter problems; linkage analysis; restricted projection algorithm; recombination fraction.; | |
DOI : | |
学科分类:生物科学(综合) | |
来源: Indian Academy of Sciences | |
【 摘 要 】
Linkage analysis is now being widely used to map markers on each chromosome in the human genome, to map genetic diseases, and to identify genetic forms of common diseases. Two-locus linkage analysis and multi-locus analysis have been investigated comprehensively, and many computer programs have been developed to perform linkage analysis. Yet there exists a shortcoming in traditional methods, i.e., the parameter space of two-locus recombination fractions has not been emphasized sufficiently in the usual analyses. In this paper, we propose a new strategy for estimating the two-locus recombination fractions based on data of backcross family in the framework of some natural and necessary parameter restrictions. The new strategy is based on a restricted projection algorithm, which can provide fast reasonable estimates of recombination fraction, and can therefore serve as a superior alternative algorithm. Results obtained from both real and simulated data indicate that the new algorithm performs well in the estimation of recombination fractions and outperforms current methods.
【 授权许可】
Unknown
【 预 览 】
Files | Size | Format | View |
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RO201912040490963ZK.pdf | 558KB | download |