Genetic polymorphism of serotonin transporter 5-HTTLPR: involvement in smoking behaviour

Journal of genetics

Maria Angelica Ehara Watanabe1¹  Maria Helena Pelegrinelli Fungaro¹  Kalil William Alves De Lima¹  Marla Karine Amarante¹  Julie Massayo Maeda Oda¹  Sandra Odebrechet Vargas Nunes²  Roberta Losi Guembarovski¹ 

[1] Laboratory of Molecular Genetics, Department of Pathological Sciences, University Hospital, State University of Londrina, Londrina, Brazil, CEP 86051-990, USA$$;Department of Psychiatry, University Hospital, State University of Londrina, Londrina, Brazil, CEP 86051-990, USA$$

关键词: serotonin;    smoking;    5-HTT;    genetic polymorphism.;   

DOI  :  

学科分类：生物科学（综合）

来源: Indian Academy of Sciences

【 摘 要 】

Data suggest that the serotonin (5-hydroxytryptamine, 5-HT) system is implicated in the pathogenesis of multiple neuropsychiatric disorders and may also be involved in smoking behaviour since nicotine increases brain serotonin secretion. It is known that smoking behaviour is influenced by both genetic and environmental factors. The present review examines the role of the serotonin transporter gene (5-HTT) in smoking behaviour and investigating studies that showed association of 5-HTT gene with smoking. This study discusses a polymorphism which has been investigated by many researchers, as the bi-allelic insertion/deletion polymorphism in the 5′-flanking promoter region (5-HTTLPR). This gene has received considerable attention in attempts to understand the molecular determinants of smoking. Therefore, in the present study, the relationship between genetic polymorphism of serotonin transporter in smoking behaviour is reviewed considering the interactive effect of genetic factors.

【 授权许可】

Unknown