Correlations between genetic variance and adiposity measures, and gene × gene interactions for obesity in postmenopausal Vietnamese women

Journal of genetics

Nguyen Thi Lam¹  Tran Quang Binh1⁴  Yutaka Nakahori⁵  Nguyen Cong Khan²  Shigeru Yamamoto³  Le Bach Mai¹  Vu Thi Thu Hien¹ 

[1] National Institute of Nutrition, 48B Tang Bat Ho Street, Hanoi 112807, Vietnam$$;Vietnam Food Administration, Ministry of Health, 138A Giang Vo Street, Hanoi 118401, Vietnam$$;Department of Nutrition and Food Science, Ochanomizu University, 2-1-1 Ohtsuka, Bunkyo-ku, Tokyo 112-8610, Japan$$;National Institute of Hygiene and Epidemiology, 1 Yersin, Hanoi 112800, Vietnam$$;Department of Human Genetics and Public Health, Faculty of Medicine, the University of Tokushima, 3-18-15 Kuramoto-cho, Tokushima 770-8503, Japan$$

关键词: genetic variance;    lifestyle factors;    overweight;    adiposity measures;    gene × gene interaction;    human genetics.;   

DOI  :  

学科分类：生物科学（综合）

来源: Indian Academy of Sciences

【 摘 要 】

Although environmental factors are important, there is considerable evidence that genes also have a significant role in the pathogenesis of obesity. We conducted a population-based study to investigate the relationship between candidate genes for obesity (UCP1, UCP2, ADRA2B, ADRB3, LEPR, VDR and ESR1) and adiposity measures (body mass index, body fat percentage, weight, waist circumference and waist–hip ratio) in terms of individual gene and gene × gene interaction in models unadjusted and adjusted for covariates (age, years since menopause, educational level and total energy intake). Postmenopausal women with TC genotype of ESR1 gene had higher body fat percentage than those with TT genotype in the models unadjusted and adjusted for the covariates ($P = 0.006$ in adjusted model). In multiple logistic regression analysis, BsmI and ApaI SNPs of VDR genes were significantly associated with overweight and obesity. The UCP2–VDR ApaI interaction to susceptibility of overweight and obesity was first observed from logistic regression analysis, and then confirmed in the multifactor dimensionality reduction method unadjusted and adjusted for the covariates. This interaction had 69.09% prediction accuracy for overweight and obesity ($P = 0.001$, sign test). In conclusion, the study suggests the significant association of ESR1 and VDR genes with adiposity measures and the UCP2–VDR ApaI interaction to susceptibility to being overweight and obesity in postmenopausal Vietnamese women.

【 授权许可】

Unknown