Mediators of ocular angiogenesis

Journal of genetics

Balamurali K. Ambati1¹  Surekha Maddula¹  Yureeda Qazi¹ 

[1] Department of Ophthalmology, John Moran Eye Center, University of Utah, 65 Mario Capecchi Drive, Salt Lake City, UT-84132, USA$$

关键词: ocular angiogenesis;    corneal neovascularization;    retinal neovascularization;    diabetic retinopathy;    age-related macular degeneration;    retinopathy of prematurity;    VEGF;    PEDF;    Flt-1;    Flk-1;    endostatin;    angiopoietin;    erythropoietin;    Tie2;    inflammation;    complement;    gene therapy;    TLR-3;    Robo4.;   

DOI  :  

学科分类：生物科学（综合）

来源: Indian Academy of Sciences

【 摘 要 】

Angiogenesis is the formation of new blood vessels from pre-existing vasculature. Pathologic angiogenesis in the eye can lead to severe visual impairment. In our review, we discuss the roles of both pro-angiogenic and anti-angiogenic molecular players in corneal angiogenesis, proliferative diabetic retinopathy, exudative macular degeneration and retinopathy of prematurity, highlighting novel targets that have emerged over the past decade.

【 授权许可】

Unknown