Mouse models of cataract

Journal of genetics

Jochen Graw1¹ 

[1] the most frequent mutations in congenital cataracts affect genes coding for 𝛾-crystallins (gene symbol: Cryg);$$

关键词: mouse;    cataract;    mutation.;   

DOI  :  

学科分类：生物科学（综合）

来源: Indian Academy of Sciences

【 摘 要 】

Much of our knowledge about the function of genes in cataracts has been derived from the molecular analysis of spontaneous or induced mutations in the mouse. Mutations affecting the mouse lens can be identified easily by visual inspection, and a remarkable number of mutant lines have been characterized. In contrast to humans, most of the genetic mouse cataract models suffer from congenital cataracts, and only a few develop cataracts in old age. Therefore, the mouse cataract models contributed rather to the understanding of lens development than to the ageing process taking place in the lens. A prerequisite formolecular analysis is the chromosomal localization of the gene. In this review, several mouse models will be discussed with emphasis on the underlying genetic basis rather than the morphological features as exemplified by the following:the most frequent mutations in congenital cataracts affect genes coding for 𝛾-crystallins (gene symbol: Cryg);

【 授权许可】

Unknown